Publications

Research Papers

Purple R*, Sakurai T, Sakaguchi M*, Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice, Sci. Rep., 7:46247, 2017 Apr, *=corresponding authors, press release, DOI: 10.1038/srep46247.

 

Fujinaka A¥, Li R¥, Hayashi M, Kumar D, Changarathil G, Naito K, Miki K, Nishiyama T, Lazarus M, Sakurai T, Kee N, Nakajima S, Wang SH, Sakaguchi M*, Effect of context exposure after fear learning on memory generalization in mice, Mol. Brain, 2016 Jan, 9:2, *=corresponding author, ¥=equal contribution, both undergraduates, DOI: 10.1186/s13041-015-0184-0.

Received a research award from the president of the university(学長表彰).

 

Sakaguchi M*, Kim K, Yu LMY, Hashikawa Y, Sekine Y, Okumura Y, Kawano M, Hayashi M, Kumar D, Boyden ES, McHugh TJ, Hayashi Y*, Inhibiting the activity of CA1 hippocampal neurons prevents the recall of contextual fear memory in inducible ArchT transgenic mice, Plos ONE, 2015 Jun, 10(6): e0130163. *=corresponding authors

 

Arruda-Carvalho M, Akers KG, Guskjolen AJ, Sakaguchi M, Josselyn S, Frankland PW, Post-training ablation of adult-generated olfactory granule cells degrades odor-reward memories, J.Neurosci., 2014 Nov, 19;34(47):15793-803

 

Sakaguchi M and Hayashi Y, Catching the engram: strategies to examine the memory trace, Mol. Brain, 2012Oct, 5:32(359 viewed in the first 10days, 6th best viewed during the 1st month)

 

Hirota Y, Sawada M, Kida Y, Huang SH, Yamada O, Sakaguchi M, Ogura T, Okano H, Sawamoto K, Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb, Stem Cells, 2012 Aug;30(8):1726-33.

 

Sakaguchi M and Okano H. Neural stem cells, adult neurogenesis and galectins: from bench to bedside, Dev. Neurobiol., 2012 Jul;72(7):1059-67.

 

Stone S, Teixeira CM, Zaslavsky K, Wheeler AL, Canabal1 AM, Wang AH, Sakaguchi M, Lozano AM, Frankland PW, Functional Convergence of Developmentally- and Adult- Generated Granule Cells in Dentate Gyrus Circuits Supporting Hippocampus-Dependent Memory, Hippocampus. 2011 Dec;21(12):1348-62.

 

Arruda-Carvalho M*., Sakaguchi M*, Akers KG., Josselyn SA., Frankland PW., Post-training ablation of adult-generated neurons degrades previously-acquired memories., J. Neurosci., 2011 Oct 19;31(42):15113-27., *equal contribution

 

Yamane J*., Ishibashi S*., Sakaguchi M*., Kuroiwa T., Kanemura Y., Nakamura M., Miyoshi H., Sawamoto K., Toyama Y., Mizusawa H. and Okano H., Transplantation of human neural stem/progenitor cells overexpressing Galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil, Mol. Brain, 2011,4:35, *equal contribution

 

Sakaguchi M, Arruda-Carvalho M., Kang NH., Imaizumi Y., Poirier F., Okano H. and Frankland PW., Impaired spatial and contextual memory formation in galectin-1 deficient mice, Mol. Brain, 2011 Sep 1;4(1):33

 

Leslie AT., Akers KG., Krakowski A., Stone SD., Sakaguchi M., Arruda-Calvalho M., Frankland PW., Impact of early adverse experience on complexity of adult-generated neurons, Translational Psychiatry, 2011 Aug;1:e35

 

Imaizumi Y, Sakaguchi M, Morishita T, Ito M, Poirier F, Sawamoto K, Okano H, Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus, Mol. Brain, 2011 Jan 27;4:7

 

Ikeda M, Hirota Y, Sakaguchi M, Yamada O, Kida YS, Ogura T, Otsuka T, Okano H, Sawamoto K., Expression and Proliferation-Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain., Stem Cells, 2010 Nov;28(11):2017-26.

 

Hirota Y, Meunier A, Huang S, Shimozawa T, Yamada O, Kida YS, Inoue M, Ito T, Kato H, Sakaguchi M, Sunabori T, Nakaya M, Nonaka S, Ogura T, Higuchi H, Okano H, Spassky N, and Sawamoto K, Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II, Development, 2010 Sep;137(18):3037-46.

 

Sakaguchi M, Imaizumi Y, Shingo T, Tada H, Hayama K, Yamada O, Morishita T, Kadoya T, Uchiyama N, Shimazaki T, Kuno A, Poirier F, Hirabayashi J, Sawamoto K, Okano H., Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction., J. Neurochem., 2010 Jun;113(6):1516-24.

 

Akers KG, Sakaguchi M, Arruda-Carvalho M, Functional contribution of adult-generated olfactory bulb interneurons: Odor discrimination versus odor memory., J. Neurosci., 2010 Mar;30(13):4523-5

 

Yamane J, Nakamura M, Iwanami A, Sakaguchi M, Katoh H, Yamada M, Momoshima M, Miyao S, Ishii K, Tamaoki N, Nomura T, Okano HJ, Kanemura Y, Toyama Y, Okano H, Transplantation of Galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets, J. Neurosci. Res., 2010 May 15;88(7):1394-405.

 

Frankland PW, Sakaguchi M, Arruda-Carvalho M, Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?, Mol. Brain, 2008 Sep 10;1:5.

 

Ishibashi S, Kuroiwa T, Sakaguchi M, Sun L, Kadoya T, Okano H, Mizusawa H, Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke., Exp. Neurol., 2007 Oct;207(2):302-13.

 

Okano H, Sakaguchi M, Ohki K, Suzuki N, Sawamoto K, Regeneration of the central nervous system using endogenous repair mechanisms., J. Neurochem., 2007 Sep;102(5):1459-65.

 

Adachi K, Mirzadesh Z, Sakaguchi M, Yamashita T, Nikolcheva T, Gotoh Y, Peltz G, Gong L, Kawase T, Alvarez-Buylla A, Okano H, Sawamoto K, b-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone., Stem Cells, 2007 Nov;25(11):2827-36

 

Sakaguchi M, Imaizumi Y and Okano H, Expression and function of galectin-1 in adult neural stem cells., Cell Mol. Life Sci., 2007 May;64(10):1254-8.

 

Yamashita T, Ninomiya M, Acosta PH, García-Verdugo JM, Sunabori T, Sakaguchi M, Adachi K, Kojima T, Hirota Y, Kawase T, Araki N, Abe K, Okano H, Sawamoto K, Subventricular-zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum., J. Neurosci., 2006 Jun 14;26(24):6627-36.

 

Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H. A carbohydrate binding protein, Galectin-1, promotes proliferation of adult neural stem cells. Proc. Natl. Acad. Sci. USA, 2006 May 2;103(18):7112-7 (Track II direct submission)

 

Sakaguchi M, Sawamoto K, Shimazaki T, Kitamura T, Shibuya A, Okano H. A method for gene transfer, single isolation and in vitro assay for neural stem cells., Inflammation and Regeneration, 2005 Jan 25(1), 50-54,

 

Ishibashi S, Sakaguchi M, Kuroiwa T, Shimazaki T, Okano H, Mizusawa H. Human neuronal stem cells improve sensorimotor and cognitive impairment in Mongolian gerbils after ischemia., J. Neurosci. Res., 2004 Oct 15;78(2):215-23.

 

Mikami Y, Okano H, Sakaguchi M, Nakamura M, Shimazaki T, Okano HJ, Kawakami Y, Toyama Y, Toda M. Implantation of dendritic cells in the injured adult spinal cord results in activation of the endogenous neural/progenitor cells for de novo neurogenesis and axonal regeneration, leading to functional recovery., J. Neurosci. Res., 2004 May 15;76(4):453-65.

Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, Sakaguchi M, Darnell RB, Okano HJ, Okano H. Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1., Neurosci. Lett., 2004 Apr 1;358(3):157-60.


On-line publication

小柳伊代, 李若詩, 藤中彩乃, 坂口昌徳, トラウマ記憶を弱めるには – マウスの記憶・睡眠研究から考えるPTSDケア, academistJournal, 2017Jul

Sakaguchi M, Sawamoto K, Okano H, Recombinant sugar binding proteins and their functional analysis: Galectin-1, GlycoPOD, JCGGDB, 2011Sep


Others

大石誠, 中島聡美, 坂口昌徳, The importance of acute intervention for preventing generalization in PTSD patients., 医学のあゆみ, 2016Sep, v258i13, p1209-1210

 

坂口昌徳, 脳内で新生するニューロンと中枢神経再生への応用, ブレインサイエンスレビュー, 2016, 廣川 信隆(編), クバプロ(出)

 

Imaizumi Y, Sakaguchi M, Hideyuki O, Galectin., Molecular Therapy, Sentan Igaku Sha, (6),pp80-81,2007 (in Japanese)

 

Sakaguchi M, Imaizumi Y, Sawamoto K, Okano H., The carbohydrate binding protein, Galectin-1 promotes proliferation of adult neural stem cells., Cell Engineering, Yodo Sha., 2006,(25),pp912-913(in Japanese)

 

Okano H, Kohyama J, Ohba H, Sakaguchi M, Tokunaga A, Shimazaki T and Okano HJ, Neural stem cells: Isolation and self-renewal. In Tissue Stem Cells; Biology & Applications, Taylor & Francis Group, LLC, New York,2006,pp55-70

 

Sakaguchi M, Sawamoto K, Okano H., Neuro-regenerative therapy - future therapeutic strategy, new medical lecture for nurse, Nakayama Shoten,2005,pp88-92(in Japanese)

 

Sakaguchi M, Sunabori K, Sawamoto K, Okano H., Development and regeneration of nervous system., Illustration map of development and regeneration, Yodo sha,2005,pp139-148(in Japanese)

 

Ninomiya M, Sawamoto K, Sakaguchi M, Okano H., Neural Stem Cells, Igaku no Ayumi, 2005,212(10), pp865-868(in Japanese)

 

Patents

Methods for enhancing survival and/or proliferation of neural stem cells and neurite extension enhancers therefor pharmaceutical compostions containing neural stem cells assay methods and screening methods
Hideyuki Okano, James Okano, Masanori Sakaguchi, Hidehiro Mizusawa, Satoru Ishibashi
USA#20070098701

 

Agent for inhibiting proliferation of neural stem cells
Hideyuki Okano, Kazunobu Sawamoto, Masanori Sakaguchi, Jun Hirabayashi
USA#20070248592

 

Method of inducing growth of nerve stem cells
Masahiro Toda, Hideyuki Okano, Yutaka Kawakami, Yoshiaki Toyama, Yuji Mikami, Masanori Sakaguchi
USA#20050226852


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